Cooden Sea Road will be closed to through traffic from its junction with Withyham Road to north of Popps Lane for four weeks from Thursday, March 14.
The road will be closed 24 hours a day to allow East Sussex Highways to carry out carriageway reconstruction. Access will be retained for residents in adjacent roads.
A diversion route will be in place via the A259 Little Common Road, A269 London Road, Buckhurst Place, Sackville Road, Wickham Avenue and Cooden Drive.
Cllr Nick Bennett, East Sussex County Council lead member for transport and environment, said: “This is a busy road with high traffic volume, which takes its toll on the road surface.
“Therefore we need to carry out a more extensive repair than with standard resurfacing schemes, to ensure the road stays in a better condition, for longer.
“We don’t take lightly the decision to close a road for this length of time, but it is necessary to ensure the safety of our crews and of the public during work of this nature.
“We’d like to apologise to residents and motorists for any inconvenience caused and to assure people that these essential roadworks will protect the road surface for many years to come.”
Rother District Council has been notified of the work and will advise residents if there are any changes to bin collection dates.
Meanwhile, bus passengers are advised to check with their bus company for any alterations to services.
Information about all forthcoming roadworks is available on the East Sussex Highways website at www.eastsussexhighways.com