The A21 London Road will be closed between Battle Road, outside the Asda superstore, and Bohemia Road for seven nights for carriageway resurfacing.
The work begins on Monday, February 25 2019, with the road closed to through traffic from 8pm to 6am every weekday night, and is due to finish on the morning of Wednesday, March 6 2019.
Temporary two-way traffic lights will be in place to allow vehicles in and out of the superstore car park.
Cllr Nick Bennett, East Sussex County Council lead member for transport and environment, said: “This is one of the busiest roads in Hastings, which carries very heavy traffic every day.
“The daily pounding it receives takes its toll on the road, which is why we now need to resurface the carriageway, providing a smoother, safer surface for motorists.
“While we do need to close the road to ensure the safety of our workers and the public, carrying out the work overnight will allow us to keep any traffic disruption to a minimum.
“We’d ask residents to bear with us while we carry out these essential works.”
While the road will be completely closed to through traffic, crews will allow access to residents where possible, but this may be subject to delays. A signed diversion route will be in place.
More information about forthcoming roadworks is available on the East Sussex Highways website at www.eastsussexhighways.com