A total of 27 roads will be treated during the programme, covering an area of more than 320,000 square metres.
Work will take place on roads across East Sussex including in Bexhill, Blackboys, Eastbourne, Hastings and Northiam.
The four-week programme begins on Monday, September 6 and is due to be completed by Monday, October 4.
The process involves spraying the road surface with a preservative treatment which contains a natural resin that seals and strengthens the road surface. The treatment is applied to newer road surfaces and slows the natural deterioration of the road surface and helps avoid the need for additional repairs for up to five years.
Cllr Claire Dowling, East Sussex County Council’s lead member for transport and environment, said: “We are investing £800,000 in our road preservation programme, which targets the areas most at risk of wear and tear.
“Early intervention such as this helps prevent more serious damage to the road surface and prolongs the life of roads across the county.
“This work, which is just part of the county council’s £15 million maintenance programme for roads this year, will benefit motorists in East Sussex for many years.”
Affected roads will be closed to traffic with signed diversion routes in place during the work, the schedule of which is subject to change depending on the weather.
Once the road surface is dry, the roads will be re-opened and are safe to drive on immediately.
Cllr Dowling added: “We appreciate the road closures will cause some disruption but would ask road users to bear with us as this is short lived and means we won’t have to carry out more disruptive work in the near future.”
More information about the work and full details of the roads being treated is available on the East Sussex Highways website at https://www.eastsussexhighways.com/highway-schemes/preservative-works