For two weeks from Monday, September 20, both northbound lanes of Lottbridge Drove from A259 Seaside to Cross Levels Way, will be closed between 8pm and 6am.
The overnight road closures on the northbound carriageway are expected to be in place until Monday, October 1. There will be a lane closure in place on the southbound carriageway one night during the week to allow repairs to the central reservation, details of which will be publicised when confirmed.
A spokesman said: “By carrying out the work overnight, we hope to minimise disruption to motorists using this busy road.
“We appreciate that there may still be some disruption but would ask people to bear with us as the result of the work will be a smoother and safer road surface.”
During road closures, traffic will be diverted via A259 Seaside, Whitley Road, Lewes Road, Kings Drive, Rodmill Roundabout and Cross Levels Way.
On Tuesday, September 21, new safety barriers will be installed at Lottbridge roundabout during the day. The road will be open, but motorists are being warned there may be some delays.
In separate works, both southbound lanes of Lottbridge Drove will be closed overnight on Friday, October 1 to enable a preservative coat to be applied to the road surfaced.
Details of work being carried across the county by East Sussex Highways can be found at www.eastsussexhighways.com