Work will start on Monday, September 12 and continue until Friday, September 23.
Devonshire Place will be closed between 7pm and 6am, Monday to Friday; there will be no weekend working.
During the work, which will take place between Memorial Roundabout and Grand Parade, northbound traffic will be diverted via Grand Parade, Terminus Road and Trinity Trees. Southbound traffic will be diverted via Grand Parade, Burlington Place and Cornfield Terrace.
Vehicle access for residents will be maintained where possible but due to the nature of the work taking place there may be delays and the diversion route may need to be taken at times. Pedestrian access will be maintained.
An East Sussex Highways spokesperson said: “We appreciate that the closing Devonshire Place overnight for two weeks will cause some disruption to road users and residents.
“Resurfacing the road will help reduce future maintenance requirements and the road closures are essential to keep everyone safe while the repairs are carried out.
“We apologise for any inconvenience caused.”
More information, including details of the diversions, is available on the East Sussex Highways website at https://www.eastsussexhighways.com/highway-schemes/devonshire-place-eastbourne-resurfacing